Announcements and Job Listings
updated: 17 July 2009
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2009 Meetings and Conferences
8/1 - 8/5, 2009 Higher order genome architecture (Marie Curie) Edinburgh, Scotland
8/9 - 8/14, 2009 Epigenetics (GRC) Holderness, NH
8/25 - 8/29, 2009 CSHL Transcription meeting Cold Spring Harbor, NY
9/30 - 10/4, 2009 Nuclear Structure and Dynamics Symposium (EMBO) Isle sur la Sorgue, France
11/16 - 11/19, 2009 Chromatin Structure and Function Costa Rica
12/10 - 12/13, 2009 West Coast Chromatin Meeting Asilomar, CA



Job Adverts



POSITIONS: POSTDOCTORAL FELLOWSHIPS
The Institute for Cancer Research- London
THE INSTITUTE OF CANCER RESEARCH (University of London) Postdoctoral Training Fellow Section of Haemato-Oncology Sutton The Institute of Cancer Research (a College of the University of London) is a world-class cancer research organization with HEFCE RAE ratings of international excellence across all of its research programmes. In partnership with The Royal Marsden NHS Foundation Trust, we form the largest comprehensive cancer centre in Europe, dedicated to research that extends from epidemiology, genetics and molecular biology, through drug discovery and development, to cancer diagnosis and patient treatment. This makes us uniquely placed to work towards our vision that people may live their lives free from the fear of cancer as a life threatening disease. An opportunity for a postdoctoral position has arisen within the Haemato-Oncology Section (Head: Professor Mel Greaves) of the Institute of Cancer Research (Sutton, Surrey) to join a project run by the Stem Cells and Chromatin Team (Team leader: Dr Tomoyuki Sawado) (http://www.icr.ac.uk/research/research_sections/haemato_oncology/haemato_oncology_teams/stem_cells_chromatin/index.shtml).
Applicants should posses a PhD degree in Biology or other relevant discipline. Laboratory experience and knowledge of epigenetics and/or stem cell biology is essential. Some experience of ES cell manipulation (e.g. gene targeting) is essential. Successful candidates should have at least one first-author publication (or manuscript in press) in a high-quality international journal. This is an excellent opportunity to join a new research group using cutting edge technologies and specializing in epigenetics. The post is available for 36 months in the first instance with a starting salary in the range of £26,966 to £32,024 p.a. inclusive depending on skills and experience. Informal enquiries may be made to Dr Tomoyuki Sawado (Email: tomoyuki.sawado@icr.ac.uk). Please note – this address is for enquiries only and CVs must be submitted in line with the instructions below. Only candidates on the shortlist will be contacted.
For further particulars and details of how to apply, please visit our website at www.icr.ac.uk/jobs.html. Alternatively you may call our 24 hour recruitment line on 020 7153 5475 quoting reference number C229 Closing date: 5 June 2009




POSITIONS: POSTDOCTORAL FELLOWSHIPS
UNC-Chapel Hill to study epigenetics and reprogramming:
Several postdoctoral positions are available in Dr. Yi Zhang’s laboratory of the Howard Hughes Medical Institute and The University of North Carolina at Chapel Hill. The positions have been created to conduct research on the following areas of studies:
a)     The genetic and epigenetic mechanism of reprogramming, especially as related to iPS generation; b)    The molecular events surrounding paternal genome reprogramming in the zygote; c)     Epigenetic mechanisms underlying obesity and diabetic disease states.
The Zhang lab has been traditionally focused on the identification and characterization of epigenetic modifying enzymes. Recently, the lab has been using cutting edge technologies, including single cell live imaging, FACS cell sorting, and iPS generation techniques to study the function of various epigenetic factors in specific biological processes. These processes range from cellular differentiation and reprogramming to the generation of disease states. More information about the lab can be found at http://www.med.unc.edu/~zhangyi/lab.htm. Candidates with good track record and previous experience in stem cell manipulation, live cell imaging, microinjector manipulation, metabolism or diabetes are encouraged to apply. Please send your CV, and three letters of reference to:
Dr. Yi Zhang, Investigator, Howard Hughes Medical Institute
Professor, Biochemistry and Biophysics
Lineberger Comprehensive Cancer Center
The University of North Carolina at Chapel Hill yi_zhang@med.unc.edu




POSITION: POSTDOCTORAL FELLOWSHIP
INRA - Institut Jean-Pierre Bourgin (Versailles, France) on Chromatin complexes in Arabidopsis thaliana
Polycomb Repressive Complexes (PRC1 and PRC2) are key chromatin complexes in gene silencing in eukaryotes. While PRC2 complex is conserved in plants and has important functions in seed development, flowering time regulation, vernalization response or cell fate determination, the existence of a plant PRC1 complex currently remains controversial due to the fact that no homologue to the PRC1 subunits has been identified by sequence homology. Recent studies have shown that in Arabidopsis, PRC1-like complexes might function as the animal PRC1. One PRC1-like core component is likely to be LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) as it recognizes the H3K27me3 epigenetic mark as does Polycomb, a subunit of PRC1, allowing the establishment of specific repressive chromatin states.
A Post-doctoral position is available for three years in our group. It aims to study the functions and the composition of LHP1/PRC1-like complexes in Arabidopsis thaliana in order to understand the mechanism of the plant Polycomb-mediated repression. The studies will include a combination of genetic, biochemical, and molecular approaches.
The host Laboratory, Laboratoire de Biologie Cellulaire, belongs to the Institut de la Recherche Agronomique (INRA), a national public scientific and technological institute devoted to plant biology and agronomy. The IJPB has a long-standing expertise in the field of plant biology, including genomics, genetics and epigenetics, breeding, metabolism, cell biology and development and it has excellent facilities for microscopy, plant growth, molecular and cell biology. It is located on the INRA Campus in Versailles (south west of Paris)
Candidates with a strong background in epigenetics, chromatin biology and plant genomics/development as well as related technical skills (chromatin-related and RNA techniques, molecular biology, cell imaging..) are encouraged to apply.
Motivated candidates should send a CV, a letter of motivation and names and addresses of two references to Valérie Gaudin - Laboratoire de Biologie Cellulaire, UR501, Institut Jean-Pierre Bourgin, INRA - Route de Saint-Cyr, F-78026 Versailles Cedex France- valerie.gaudin@versailles.inra.fr, (http://www-ijpb.versailles.inra.fr/).



POSITION: TWO POSTDOCTORAL POSITIONS AVAILABLE AT NCI/NIH
One senior and one junior non-FTE postdoctoral positions are available starting January 1, 2009 in Dr. Yamini Dalal’s laboratory at the National Cancer Institute at NIH in Bethesda, MD (http://ccr.cancer.gov/staff/staff.asp?profileid=14116).
Salary and benefits are extremely competitive and commensurate with qualifications. These positions are open to all candidates regardless of citizenship. Working at the NIH is an excellent opportunity and a nurturing environment for young, ambitious and hardworking scientists to excel, Our chromatin and cancer related scientific community is unparalleled in the breadth and scale of the work being done in the Center for Excellence in Chromosome Biology and the Center for Cancer Research (http://ccr.nci.nih.gov/initiatives/CECB/Members.aspx). Living in the Washington DC metro area comes with all the attendant benefits of an urban capital immersed in culture, art, and government, surrounded by exceptional natural beauty to be found in the nearby woods and mountains of the Appalachian range. New York and Philadelphia are a short drive or train ride away.
Position Descriptions:
A)    An exceptionally talented and motivated senior postdoctoral candidate is sought to work on CenH3 nucleosome and changes during the cell cycle, focusing on changes at G2/M and functional aspects of CenH3 nucleosome within the mitotic chromosome.
Requirements: Ph.D. awarded from a U.S. or equivalent academic institution no later than 2005, no more than 5 years of postdoctoral experience in a chromatin-based or related laboratory setting, 5 or more research publications in peer-reviewed international journals. Research skill set is expected to be excellent in biochemical assays. Preferred skills: microscopy using EM/AFM and/or experience with ultra-centrifugation and sedimentation analysis. 

B)    An exceptionally motivated and creative junior postdoctoral candidate is sought to work on mis-regulation of CenH3 expression, assembly and disassembly kinetics and effects on centromere function in vivo. Requirements: Ph.D. awarded from a U.S or equivalent academic institution no earlier than 2005, research experience in a chromatin-based or related laboratory setting, 2 or more research publications (at least one first author publication) in peer-reviewed international journals. Research skill set is expected to be excellent in genetics and microscopy based methodologies and/or biochemical assays.
Interested candidates should contact Dr. Dalal via email (dalaly@mail.nih.gov), provide a detailed CV, copies of representative publications, and a short summary of research interests. In addition, please have 3-5 referees write electronically (dalaly@mail.nih.gov), or by mail, in support of your candidacy no later than December 1st, 2008.
Mail address
: D702H, Bldg 41, 41 Library Drive MSC 5055, National Institutes of Health, Bethesda, MD 20892-5055.




POSITION: POSTDOCTORAL FELLOWSHIP
Chromatin remodeling in budding yeast/Epigenetic silencing of tumor suppressor genes
The University of Florida Shands Cancer Center
As part of ongoing programmatic development in epigenetics within the UF College of Medicine, two postdoctoral positions (two-year initial commitment) are available for studies on mechanisms of: 1) chromatin remodeling at the yeast PHO5 promoter or 2) epigenetic silencing of tumor suppressor genes. The positions will require expertise in molecular genetics and/or biochemistry. Previous experience in yeast or mammalian systems is desirable but not essential. Both areas of study will take advantage of our powerful population and single-molecule technologies (MAP and MAP-IT) for probing chromatin structure with DNA methyltransferases. For more detailed information about these projects and our interests, please contact me (352-273-8142) or see our recent publications:
Jessen WJ et al. 2006. Active PHO5 chromatin encompasses variable numbers of nucleosomes at individual promoters; Nat. Struct. Mol. Biol. 13, 256-263. Dhasarathy A and Kladde MP. 2005. Promoter occupancy is a major determinant of chromatin remodeling enzyme requirements. Mol. Cell. Biol. 25, 2698-2707.
Carvin CD et al. 2003. Targeted cytosine methylation for in vivo detection of protein-DNA interactions. Proc. Natl. Acad. Sci. 100, 7743-7748.
Kilgore JA et al. 2007. Single-molecule and population probing of chromatin structure using DNA methyltransferases. Methods. 41, 320-332.
Interested individuals should send a CV and names of three references by email to: kladde@ufl.edu or by mail to:
Mike Kladde, Department of Biochemistry and Molecular Biology, 1376 Mowry Rd., Box 103633, Gainesville, FL 32610-3633.